Vitamin D 25-Hydroxy (Quest)


This blood test measures Vitamin D 25 (OH) levels. Vitamin D, known as the “sunshine vitamin.” Vitamin D is a fat-soluble prohormone that the body can synthesize as Vitamin D3 (cholecalciferol) when the skin is exposed to ultraviolet-B (UBV) rays from the sun. Vitamin D is needed for strong bones and teeth, Vitamin D helps your body absorb the amount of calcium and phosphorus it needs. It also has other roles in the body, including modulation of cell growth, neuromuscular and immune function, and reduction of inflammation.

Though controversial at times, research demonstrating the importance of Vitamin D3 continues to accumulate, while illuminating the threats that low levels pose to overall health and well-being. There are associations between low Vitamin D levels and peripheral vascular disease, certain cancers, multiple sclerosis, rheumatoid arthritis, juvenile diabetes, Parkinson’s, and Alzheimer’s disease.In May of 2009, an article published by William B. Grant, PhD of the Sunlight, Nutrition, and Health Research Center (SUNARC) demonstrated that a strong correlation exists between Alzheimer’s and Vitamin D deficiency. In 2010, it was reported at the Alzheimer’s Association International conference in Hawaii that older men and women with low levels of Vitamin D were approximately four times as likely to suffer from memory deficits. There are two primary ways that people lose teeth – dental caries and periodontal disease. Both conditions are linked to low Vitamin D levels. Low serum Vitamin D levels have been associated with a rise in the incidence of cardiovascular diseases, diabetes mellitus, depression, dental caries, cancer, osteoporosis, and periodontal disease, all of which are either considered risk factors for dementia and cognitive decline. Low Vitamin D levels also plays a role in hypertension, chronic pain, muscle weakness, muscle wasting, pre-term births as well as birth defects and autoimmune diseases and the list is mounting. In 2008, a number of studies reported that those with higher Vitamin D serum levels had greatly reduced risk of incidence or death from cardiovascular diseases. Research has shown that Vitamin D is neuroprotective and plays a vital role in reducing inflammation and plays an integral role in brain development and function. Vitamin D may also remove toxins from brain tissue. Some researchers are declaring Vitamin D deficiency as “pandemic”. Research has shown that 41% of outpatients in the United States between the ages of 49-83 had low circulating Vitamin D levels. In the first year of being institutionalized, almost all elderly people are at risk for becoming Vitamin D deficient. Vitamin D is critical for everyone’s optimal health.

Test Preparation For Optimal Results
If possible, have the lab collected early in the morning or shortly after waking. For comparison purposes, have subsequent labs collected close to the same time.

Disclaimer: Your health-care provider should evaluate a deviation from normal ranges.