Wheat Burden – Wheat Gluten Autoimmunity Reactivity Profile

Cyrex Laboratories WheatBurden™ is an advanced wheat and gluten immune reactivity blood test designed to detect antibody responses to processed wheat proteins found in the foods people actually eat—bread, pasta, tortillas, sourdough, and baked/fermented wheat products.

Most “gluten tests” focus on raw wheat proteins or a limited set of gluten peptides, which may miss reactions triggered by heat, baking, and fermentation. WheatBurden™ closes that gap by measuring the total immune burden of wheat and gluten across multiple forms, including cooked, raw, and peptide exposures—reflecting how modern processing can change how the immune system recognizes wheat.

Why food processing matters

Heat and fermentation can modify wheat proteins in ways that may:

• alter or destroy existing immune targets (epitopes)
• reshape protein structures
• expose new immune-reactive targets

This means some people may react differently to cooked or fermented wheat than they do to standard gluten peptide markers.

What WheatBurden™ measures

WheatBurden™ provides Cyrex-quality antibody profiling to help identify potential immune activation related to:

• multiple cooked wheat food forms (real-world exposures)
• yeast-fermented wheat products (including common dough preparations)
• commonly reactive wheat and gluten peptides
• gluten-related enzymes

This expanded panel includes seven additional processed-wheat markers, offering a more comprehensive look at wheat-related immune stress as it occurs in the modern diet.

Who may benefit

WheatBurden™ may be helpful for individuals who experience symptoms after eating wheat-based foods—especially when standard testing is inconclusive—and for clinicians evaluating chronic inflammation, immune activation, or autoimmune-pattern concerns.

WheatBurden™ is supported by more than two decades of functional immunology research associated with Cyrex Laboratories’ scientific leadership, including peer-reviewed work examining how food processing can create antigenic forms not detected by raw-food-only testing.

Note: This test assesses immune reactivity and is not a standalone diagnostic for celiac disease. Results should be interpreted with a qualified healthcare professional in the context of symptoms and medical history.

Turn Around Time

12-14 Days 3 to 5 days (May take longer based on weather, holiday or lab delays)

Collection Instructions

Cyrex serum specimens may be drawn in-office or at the lab location of your choosing (not Quest or Lap Corp), it does not need to be at a Cyrex contracted facility. The client is responsible for any fees incurred when utilizing a non-Cyrex-contracted phlebotomy service provider. Phlebotomy and shipping instructions are provided in every collection kit. Please note: Cyrex-contracted phlebotomy service providers do not perform collection for clients under the age of 16.

Testing not available in NY.