Glucose-6-Phosphate Dehydrogenase (G6PD) Quant Blood and RBC


This blood test is used to detect a Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency. G6PD is found in all human cells but plays a significant role in red blood cells. Glucose-6-Phosphate Dehydrogenase is an enzyme that uses metabolic reactions to support the cell’s ability to keep glutathione in its reduced form and support the metabolic roles that support vitamin C and E’s antioxidant functions.

G6PD deficiency is a sex-linked trait and is the most prevalent enzyme deficiency in the world. Approximately 400 million people live with this enzyme deficiency. It is most prevalent in people of Mediterranean, African and Asian descent. Glucose-6-Phosphate Dehydrogenase deficiency is also known as favism and primaquine sensitivity. Other substances that should be used with caution in those affected with G6PD deficiency are antimalarials and sulfonamide antibiotics. Questions have been raised about the safety of vitamin C use in G6PD deficient persons. The iron level in G6PD deficient cells may interact with the Vitamin C causing red blood cells to rupture promoting a hemolytic crisis. To prevent complications, administration of Vitamin C in those affected by a G6PD deficiency should be closely observed.

Test Preparation For Optimal Results:

If possible, have the lab collected early in the morning or shortly after waking. For comparison purposes, have subsequent labs collected close to the same time.

Disclaimer: A health care provider should evaluate a deviation from normal ranges.