Estrogens, Total


This blood test is used to measure total circulating estrogens. The three major naturally occurring estrogens are present in significant quantities in blood. They are estradiol (E2), estrone (E1) and estriol (E3). Because estradiol and estrone fluctuate during a woman’s cycle and menopause, some providers prefer this test when evaluating estrogen levels. Estrogen’s role in supporting health and well-being is as significant as it is diverse. To name a few, estrogen affects emotions moods, attention and language skills.


Evidence is mounting suggesting that estrogen exposure reduces the risk and slows the onset and progression of Alzheimer’s disease. Recent research has documented that estrogen decreases the inflammatory responses associated with dementia and other neurological disorders. The brain protects itself by producing neuroprotective estradiol in response to threatening inflammatory processes that injure brain tissues. Endocrine disruptors such as heavy metals and environmental toxins, processed foods and chronic stress may contribute to an imbalance of the natural production of estrogen.

Test Preparation For Optimal Results:

If possible, have the lab collected early in the morning or shortly after waking. Do not take supplements on the day of the test. For comparison purposes, have subsequent labs collected close to the same time.

Disclaimer: Your health care provider should evaluate a deviation from normal ranges.

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