Blood Test Kit

IgG Food Allergy Test with Candida – Mosaic Diagnostics Blood Spot Test Kit

$325.00

ASSESSES 190 FOODS Including Hemp as a Food Source as Medical CBD

Includes a wide range of foods, common in the Western, Asian, and Mediterranean diets. We have added a hemp allergy marker because it is very common now as a food source or as medical CBD. We are able to run the IgG Food MAP on both serum and dried blood spot samples.

SUPERIOR SENSITIVITY AND ACCURACY COMPARED TO ELISA

GPL’s xMAP® immunoassay with fluorescence readout has proven to be even more sensitive than ELISA tests. The IgG Food MAP test detects all food antibodies with greater precision than ELISA tests thanks to the superior technology we’ve developed for the test.

UPGRADED TECHNOLOGY

Antigen-specific IgG antibodies are captured on multiplexed magnetic beads, using xMAP® (Multiple Analyte Profiling) technology. The xMAP® bead-based immunoassay allows for the simultaneous detection of IgG antibodies to all 190 foods in two single test wells, reducing sample volume requirements and reagents while increasing sensitivity and specificity as compared to traditional plate-based ELISA tests. The upgraded immunoassay is cost and time effective, easy to perform and reproducible. We have now fully automated all steps of our testing processes, leading to even better precision.

GREATER RELIABILITY OF RESULTS

In the multiplexed bead-based immunoassay, food antigenic proteins are first covalently bound to beads. The beads are mixed with the patient’s sample where bead-bound antigens capture the specific IgG antibodies present in the sample. The food-specific IgG antibody level of each sample is detected with a fluorescent-labeled antibody against IgG. Every reaction with a patient sample also contains control beads to ensure accurate results. The fluorescent signal is measured using an xMAP® analyzer. The amount of food-specific antibody detected per allergen specific bead is directly proportional to the fluorescent signals. The higher the fluorescence, the more specific IgG antibodies are present in the sample. Once test results are available for review, our Quality Assurance (QA) team carefully verifies that quality control measures are within instrument and assay specifications.

TESTS FOR SPECIFIC FOOD ANTIGENIC PROTEINS

Detection to multiple analyte detection. The multiplexed, bead-based assay only detects IgGs against food antigenic proteins that were covalently bound to the beads, making this assay more specific to proteins than the ELISA. In the ELISA, there is no covalent binding of proteins; instead, proteins or other antigens are bound to the surface of a plastic well by adsorption. This non-specificity of the surface allows the binding of glycan-rich molecules such as Candida and yeast. Because of this, GPL is providing a separate report for the yeasts which will be tested by ELISA, rather than the xMAP® immunoassay.

WHAT IS IGG?

IgG is the major antibody found in serum. IgGs are composed of two fragment antigen binding (Fab) regions that contain the antigen binding sites and the Fc region, which is responsible for most of the biologic activity of the antibodies (Figure 1). An antigen is a substance that causes the immune system to produce an antibody that specifically reacts with it. IgG-mediated reactions to food antigens may be delayed by several hours or days, whereas IgE food antibody reactions are quite immediate.

Human IgG is separated into four subclasses denoted IgG1, IgG2, IgG3, and IgG4. Each subclass varies in abundance and biological function. IgG1 and IgG3 are predominantly responsible for antibody protection against reinfection. IgG2 antibodies are opsonic (marking a pathogen for ingestion and destruction) and develop in response to carbohydrate polysaccharide antigens. IgG4 molecules function as skin-sensitizing immunoglobulins and are thought to block antibodies produced in response to chronic exposure to antigens.

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IgG antibodies provide long term resistance to infections and have a much longer half life than the traditional IgE allergy. Symptoms may occur hours or days after the offending food has been eaten. The 93 foods tested in the IgG Food Allergy Test w/ Candida can identify problem food so it can be eliminated from the patient’s diet. This elimination of IgG positive foods can improve symptoms of irritable bowel syndrome, autism, AD(H)D, cystic fibrosis, rheumatoid arthritis, and epilepsy according to numerous clinical studies.

The Great Plains Laboratory, Inc. has added Candida to the IgG Food Allergy Test. Candida problems are caused when the benign yeast form of Candida albicans mutates to its fungal form. Candida can take over sections of the intestinal wall causing numerous symptoms. As it grows out of balance it produces toxins that create holes in the intestinal lining, leading to leaky gut syndrome. After entering the blood, Candida albicans causes an inflammatory immune system response. A wide range of disorders have been linked to Candida including autism, multiple sclerosis, depression, and chronic fatigue. Use of antibiotics, oral contraceptives, chemotherapy, and anti-inflammatory steroids greatly increase susceptibility to Candida.
 
The Benefits of Testing
  • Helps determine if food reactions are contributing to physical or mental symptoms
  • Removal of highly reactive foods from the diet is a non-invasive, food-based therapy that often mitigates a patient’s symptoms
  • Research and clinical studies suggest food allergies identified by IgG testing can be a major contributing factor in many chronic health conditions
  • Food rotation and elimination diets can reduce stress on the immune system, lower gut inflammation, resolve food cravings, and reduce the potential for eating disorders

Candida albicans Scale in IgG Food Allergy Test

The Candida albicans scale has been updated to account for the observation that Candida-specific immunoglobulins are present in the specimens of virtually all individuals tested. The new scale is intended to provide a clearer indication of clinical significance and was established according to population percentile ranks obtained from a random subset of 1,000 patients. Specifically, the range of insignificant and low IgG values correspond to the first and second quartiles of the distribution, while moderate values denote individuals in the 51st to 97.5th percentiles. Those with an IgG value greater than the 97.5th percentile are considered to have a high concentration of Candida-specific immunoglobulins.

IgG Candida Scale
  • 0-25th percentile: Insignificant
  • 26th-50th percentile: Low
  • 51st-97.5th percentile: Moderate
  • 97.5th and higher: High

Specimen Requirements: The IgG Food Allergy Test is available thru Dried Blood Spot collection.

Dried Blood Spot (DBS): Five full circles of dried blood on the protein saver card is required.
Please note that the elimination of food prior to sampling will reduce the ability for our laboratory to detect antibodies (allergies) to that food.


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