Urine Porphyrin Testing – Doctors Data (Test Kit Urine)


Porphyrins are proteins involved in the formation of heme measured in urine. Heme is essential for the proper function of many proteins including oxygen transport, energy production, and detoxification. Proper porphyrin production is essential for our body’s capacity to detoxify toxins.

Porphyrins are particularly well suited for evaluating heavy metal toxicity. The heme pathway is a constantly-changing metabolic pathway that is active in almost every cell of the body. Disturbances in this pathway may cause an accelerated accumulation of porphyrins. It is important to know that these specific enzymes are produced in the heme pathway and are found all over the body and are highly sensitive to the presence of various toxins, creating the large accumulation of porphyrins in the pathway.


Porphyrias are actually a group of disorders that have been considered rare in the past. Research suggests that porphyria may be an autoimmune disease. They result in a required portion of hemoglobin – heme – not being produced properly. While porphyrias are not considered to be autoimmune diseases, there is a very strong similarity between themPorphyria is a group of diseases in which substances called porphyrins build up, negatively affecting the skin or nervous system. Porphyria can be triggered by medications such as: barbiturates, tranquilizers, birth control pills, sedatives and may also be triggered by chemicals, fasting, smoking, drinking alcohol, infections, emotional and physical stress, fluctuations in hormones, and exposure to the sun. Attacks of porphyria develop at different rates and can develop over hours or days and last for days or weeks.

Urine Porphyrin’s may be useful for evaluating health challenges such as:

  1. Anemia
  2. Autism
  3. Genetic Disorders
  4. Nutritional Deficiencies
  5. Oxidative Stress
  6. Toxic Chemical
  7. Metal Exposure

Abnormal levels of urinary porphyrins, oxidized metabolites of heme biosynthesis, are associated with genetic disorders, metabolic disturbances and diseases, anemias, oxidative stress, and high-level exposure to toxic chemicals or metals. Specific urine porphyrin profiles are associated with high-level exposure to mercury, arsenic, lead and some chemicals and drugs. Precoproporphyrins, associated with mercury, are reported separately and per unit of uroporphyrin to increase detection even when heme biosynthesis is low.

This non-invasive test requires a single first morning void (FMV) or 24-hour urine collection.

Turnaround Time

3 to 5 days days once the lab receives the specimen.

(May take longer based on weather, holiday or lab delays)

Sample Report 

Collection Instructions


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