Biome Burden™ Profile by Cyrex Labs

What Is the Cyrex BiomeBurden Complete Test?

The Cyrex BiomeBurden Complete test takes a deeper look at how your immune system is responding to certain yeasts, molds, and microorganisms associated with the intestinal environment. Instead of looking only for organisms in a stool sample or culture, this blood test measures IgG and IgA antibody patterns that may indicate immune recognition or activation.

The panel evaluates immune responses associated with several Candida species, Saccharomyces strains, food-derived molds, and selected intestinal pathogens. It also includes less commonly measured markers such as Actin Peptide, Candidalysin, Alpha-Enolase, and Ubiquitin. These markers may provide additional information about microbial exposure, tissue stress, and immune activity that may not appear on routine testing.

Looking at these markers together may help identify patterns worth exploring in people experiencing persistent digestive problems, fatigue, brain fog, skin concerns, sinus symptoms, or recurring infections. The results do not diagnose the cause of these symptoms, but they may provide another piece of the root-cause puzzle.

Why Is the BiomeBurden Complete Test Important?

Sometimes symptoms continue even when standard blood work, cultures, or stool testing appear normal. The BiomeBurden Complete panel approaches the problem differently by evaluating how the immune system is responding rather than simply asking whether a particular organism is present.

Certain markers may reflect immune responses associated with microbial activity, tissue irritation, or cellular stress. For example, antibodies involving Alpha-Enolase or Ubiquitin may suggest increased immune recognition of proteins released or exposed during cellular stress. Neutrophil Activation Factors may offer insight into whether innate immune defenses are being repeatedly stimulated.

Because the panel measures both IgG and IgA antibodies, it provides information about immune activity in different parts of the immune system. These results should be interpreted as patterns of immune recognition. IgA should not automatically be labeled as a “recent” response or IgG as an “old” response without considering the full clinical picture.

The panel also evaluates immune responses to several Candida species individually. This matters because Candida strains do not always interact with the immune system in the same way. Information related to Th1, Th2, Th17, and regulatory T-cell activity may provide a broader view of whether the immune system appears to be leaning toward inflammation, allergic-type reactivity, impaired tolerance, or difficulty regulating microbial exposure.

Why Consider Ordering This Gut-Related Test?

You may want to consider the BiomeBurden Complete test when persistent symptoms remain unexplained after more routine testing. It may be especially useful when yeast, food-related mold exposure, intestinal microbes, or abnormal immune signaling are suspected but have not been clearly identified.

This test may be worth discussing with your healthcare practitioner if you experience:

* Ongoing bloating, abdominal discomfort, or changes in bowel habits
* Recurring sinus, skin, or yeast-related concerns
* Fatigue, brain fog, or mood changes without a clear explanation
* Symptoms that appear to worsen after fermented foods or high-sugar meals
* Chronic symptoms despite routine laboratory results being within range
* A need for a more detailed look at immune responses to microbial antigens

The results may help you and your practitioner decide whether further investigation is appropriate. They may also support more individualized decisions involving diet, environmental exposures, gut support, or treatment. The goal is to replace guesswork with better-informed clinical questions.

What the BiomeBurden Complete Test May Reveal

* Immune reactions associated with Candida species, molds, Saccharomyces, and selected gut microbes
* Possible patterns of microbial burden or persistent immune activation
* Information related to Th1, Th2, Th17, and regulatory T-cell activity
* Immune patterns that may be relevant to chronic digestive, skin, sinus, cognitive, mood, or fatigue-related concerns
* Findings that can be considered alongside symptoms, medical history, and other laboratory results

Selected Biomarkers Included in the BiomeBurden Complete Panel

Candida albicans IgG and IgA – Measures immune recognition of a common yeast that can inhabit the gastrointestinal tract and other mucosal surfaces. Increased immune reactivity or repeated exposure to Candida-related antigens. It does not, by itself, confirm Candida overgrowth or infection.
Food-Derived Molds IgG and IgA – Evaluates immune responses to molds associated with certain foods. Heightened immune recognition of mold antigens. Results should be interpreted with dietary history, symptoms, and possible environmental exposures.
Th1/Th2 Ratio –  Provides information about the balance between different immune-response patterns. Th1 activity is generally associated with cellular immune defense, while Th2 activity is more closely associated with antibody and allergic-type responses. A higher ratio may reflect a stronger Th1 pattern. A lower ratio may reflect a stronger Th2 pattern. Neither result is automatically good or bad and must be interpreted in context.
Ubiquitin IgG and IgA – Measures immune recognition involving ubiquitin, a protein associated with normal cellular maintenance and the handling of damaged proteins. Increased immune recognition that may occur alongside cellular stress, tissue irritation, or broader immune activation.
Saccharomyces cerevisiae Glucan IgG and IgA – Evaluates immune responses to components of Saccharomyces, a yeast found in some fermented foods, baking products, supplements, and probiotics. | Heightened immune recognition of Saccharomyces-related antigens. It does not automatically mean fermented foods or probiotics must be avoided.

An Important Note About Your Results

The BiomeBurden Complete test is not intended to diagnose an infection, prove that a microorganism is actively growing in the gut, or determine treatment on its own. Antibody results show immune recognition, which can be influenced by exposure, intestinal permeability, immune regulation, and other health factors.

For the clearest interpretation, results should be considered alongside your symptoms, health history, medications, diet, environmental exposures, physical findings, and other laboratory testing. A knowledgeable functional or integrative healthcare practitioner can help determine which findings are clinically meaningful and which may simply reflect previous or ongoing exposure.

What You’ll Receive

• At-home blood collection kit (fingerstick or via phlebotomy)

• Secure online results within 2–3 weeks of lab receipt

• Optional consultation or interpretation support via MyLabsForLife

Important Notes

• This is a direct-to-consumer test and is not eligible for insurance reimbursement.

• MyLabsForLife provides access to this test for informational and wellness purposes only. Please consult a licensed healthcare provider to interpret your results in the context of your medical history.

• For the most accurate results, avoid immunosuppressants (including steroids) for 7 days before sample collection unless advised otherwise by your provider.

• This test in not available in the state of New York.

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Explore the hidden microbial stressors that may be undermining your health.
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Results:
Samples will be processed within 21 business days of receipt at the laboratory.
A copy of your test results will be emailed to you from MyLabsForLife.

Test Preparation for Optimal Results:

This is a Serum (blood) test.

Cyrex Laboratories Blood Draw Instructions will be mailed with a Test Requisition and specimen collection kit upon receipt of payment by MyLabsforLife. MyLabsForLife does not cover the cost of blood sample processing.

Fasting is not required, but please abstain from consuming overly fatty foods prior to your blood draw to avoid sample rejection.
Corticosteroid use and immunosuppressant drugs affect antibody production and therefore may impact test results.

Please consult with your healthcare provider before testing if you are taking these medications.