Doctor’s Data offers the Metabolomic Profile due to increasing awareness of the need to detect Metabolic syndrome before it progresses to adult-onset diabetes and related health consequences. The profile is designed to assess the likelihood of Metabolic syndrome in at-risk patients. Metabolic syndrome may occur at all stages in life. The number of people with Metabolic syndrome has increased over the last two decades. In 2006 it was estimated that 13% of US adolescents, 24% of young – midlife adults, and 40% of senior adults (> 70 y.o.) have Metabolic syndrome.
Although the number of people with Metabolic syndrome is increasing, human genetics have not. Epigenetic, controllable factors clearly play a role in the development of Metabolic syndrome. Contributing factors may include obesity, insulin resistance, polycystic ovary disease, hormone imbalance or a sedentary, unhealthy (smoking, etc.) lifestyle. “Over nutrition” and poor dietary choices (highly processed, high fat, high salt, high sugar “empty-calorie” foods), combined with sedentary habits interact with our genetic programming: we store extra calories as fat. Fat cells (adipocytes) produce hormones (adipokines) that interact with the hypothalamus and or immune system and may have pro-inflammatory or anti-inflammatory effects. Altered adipokine levels have been observed in Metabolic syndrome. The biomarkers that constitute the Metabolomic Profile include:
Hemoglobin A1c (HbA1c) – estimates the average blood glucose concentration for the life of the red blood cell (120 days)
Insulin – levels of insulin elevate early in type II diabetes, and then decrease as pancreatic beta cells lose function
High sensitivity C-reactive protein (hs-CRP) – estimates the risk of cardiovascular disease
Leptin – leptin is a hormone produced by adipocytes to provide a satiety signal to the hypothalamus. Elevated circulating levels of leptin are associated with adipose tissue abundance, and a leptin resistance may ensue. High levels of this adipokine may have pro-inflammatory effects, and leptin accelerates arterial foam cell formation.
People that may especially benefit from the Metabolomic Profile include those with:
• Increased waist size or body mass index (BMI) >30
• High triglycerides or need for cholesterol medication
• Low HDL cholesterol or need for cholesterol medication
• Hypertension or need for hypertension medication
• Fasting Glucose > 100 mg/dL • Family or personal history of cardiovascular disease, high cholesterol or type II diabetes
• Personal history of chronic inflammatory disease
Except for obesity, the risk factors for Metabolic syndrome, and the chronic diseases that may develop from it, may present no symptoms until well advanced. The greatest window of opportunity to prevent the development of atherosclerosis, type II diabetes or heart failure may occur during the early, symptom-free stages of Metabolic syndrome. Early detection and intervention through diet and lifestyle changes may prevent the development of symptoms or disease complications. The Metabolic Profile facilitates clinicians in the early detection of Metabolic syndrome.
3 to 5 days (May take longer based on weather, holiday or lab delays)