Estrone (E1)


This blood test measures Estrone (E1). Estrone (E1) is one of the three naturally produced Estrogens. Estrone is the least abundant of the three and is relevant to health and disease because it is considered the strongest acting estrogen. In post-menopausal women, estrone is produced by the adrenal’s instead of the ovaries and is the dominant estrogen.

Estrone is significant to health and wellness because of its conversion to estrone sulfate, which acts as a reservoir that can be converted to estradiol when needed. Estrogens role in supporting health and well-being is as significant as it is diverse. To name a few, estrogen affects emotions moods, attention and language skills. Evidence is mounting suggesting that estrogen exposure reduces the risk and slows the onset and progression of Alzheimer’s disease. Recent research has documented that estrogen decreases the inflammatory responses associated with dementia and other neurological disorders. The brain protects itself by producing neuroprotective estradiol in response to threatening inflammatory processes that injure brain tissues. Endocrine disruptors such as heavy metals and environmental toxins, processed foods and chronic stress may contribute to an imbalance of the natural production of estrogen. In post-menopausal women, the balance of all estrogens is crucial to support health and wellness. Abnormally high levels of estrone have been associated with cardiovascular disease, stroke and certain types of cancer.

Test Preparation For Optimal Results:

If possible, have the lab collected early in the morning or shortly after waking. For comparison purposes, have subsequent labs collected close to the same time.

Disclaimer: A health care provider should evaluate a deviation from normal.