Dr. Amy strategically constructed this panel in order to review a broader perspective of thyroid function. Thyroid hormone production is not only dependant on a complicated hormone synthesis process, optimal thyroid function is also dependant on a multitude of cofactors, many of those cofactors are evaluated in this panel in concert with specific thyroid function tests.
Thyroid hormone production is regulated by a feedback loop between the hypothalamus, pituitary gland, and the thyroid gland. Hypothalamic thyrotropin-releasing hormone (TRH) stimulates pituitary thyrotropin (TSH) synthesis and secretion. In turn, TSH stimulates production and release of T4 and T3 from the thyroid gland. When enough T4 is produced, it signals to TRH and TSH that there is enough thyroid hormone in circulation and not to produce more. About 85% of the hormone produced by our thyroid gland is T4, which is an inactive form of the hormone. After T4 is made, a small amount of it is converted into T3, which is the active form of thyroid hormone. To complicate matters, T3 also gets converted into either Free T3 (FT3) or Reverse T3 (RT3). It is the Free T3 that really matters in all of this, since it’s the only hormone that can attach to a receptor and cause your metabolism to rise, keep you warm, keep your bowels moving, mind working, and other hormones in check. The role of Reverse T3 is not well known, however, Dr. Amy has seem it elevated in persons under extreme stress and those who have mercury toxicity.
And finally, Hashimoto’s thyroiditis, an autoimmune disease, is the most common form of hypothyroidism and its numbers are rising annually. Hashimoto’s thyroiditis is an autoimmune disease is one in which your body turns on itself and begins to attack a certain organ or tissue believing its foreign. Dr. Amy routinely screens all of her patients for autoimmune thyroid disease by ordering Thyroid Peroxidase Antibodies (TPOAb) and Thyroglobulin Antibodies (TgAb).
Test Preparation for Optimal Results:
- If possible, have the lab collected early in the morning or shortly after waking. For comparison purposes, have subsequent labs collected close to the same time.
- To optimize your test results, it is recommended that you fast for 10 -12 hours (water only).
- Refrain from taking supplements (especially those that contain Vitamin A) for at least 72 hours before a Selenium and Vitamin A test.
- Your test results should be finished processing in 10 -14 business days.
- When your results have finished processing, a copy will be sent directly to you.
Your health care provider should evaluate a deviation from normal ranges.