DNA testing is on the rise due to scientific research in the area of genetics in concert with the ability to offer affordable testing. DNA / SNP testing offers the opportunity and ability to individualize and personalize the care for so many who are suffering from the inability to have optimal methylation and detoxification pathways working optimally which lead to so many of the diseases of civilization that we are all witnessing such as escalating rates of infertility, mitochondrial dysfunction, neurotransmitter imbalance, schizophrenia, bipolar disorder, autism and other neurodegenerative diseases to name a few.
The DNA Methylation Pathway Profile offers the opportunity via blood spot testing for you learn single nucleotide polymorphisms, or SNPs may impact or potentiate your health. DNA methylation testing offers the opportunity to review the potential of important biochemical processes such as methionine metabolism, detoxification, hormone balance and Vitamin D function. The presence or absence of SNPs may modify disease risk. The risks may be reduced by lifestyle changes, and inefficient biochemical processes can be supported by diet and nutritional supplements to maximize the functions of metabolic pathways.
Identifying single nucleotide polymorphisms (SNPs) that may influence health and risk for diseases facilitates clinical support for patients. The Doctor’s Data DNA Methylation Pathway Profile includes a variety of SNPs known to influence many aspects of health including:
- Insulin Sensitivity
- Bone Health
- Cancer Risks
- Cardiovascular Health
- Detoxification Processes
- Mitochondrial Function & Metabolism
- Neurotransmitter Balance
- Bipolar Disorder
- Neurodegenerative Diseases
- Impaired Nitric Acid Metabolism
- Oxidative stress
- Congenital Heart Disease
- Increased risk for Down syndrome
SNPs are DNA sequence variations that occur relatively frequently in the general population. They are different from disease mutations, which are very rare. Huntington’s disease is an example of a disease mutation – if you inherit the altered gene, the disease will develop. Certain SNPs may be associated with particular health conditions, but they are not known to directly cause disease. The majority of SNPs affect protein, enzyme or cell receptor structure and function.
The identification of SNPs and their impact on health and physiology is an ongoing area of research – the hope is that finding and studying these small variations in DNA will lead to better and more individualized medical interventions. In many cases the environment – diet, nutrition, toxicant exposures, stress – may further modify the expression of genes and SNPs.
The SNPs affecting detoxification and methylation become even more important if a patient has been exposed to the toxicants such as mercury, lead or bisphenol A (BPA). Lead and BPA inhibit the function of methyltransferases, and mercury inhibits methionine synthase, an important enzyme in the re-methylation of homocysteine. Methylation is an essential step in the detoxification and elimination of arsenic and other xenobiotics. Normal methionine metabolism is a critical component of Phase II detoxification processes; the B-12 and folate-dependent transmethylation and B-6 dependent transsulfuration pathways convert homocysteine to cysteine. Cysteine is an important precursor in glutathione biosynthesis.
The greatest difficulty in interpreting SNP results is determining the extent to which a DNA genotype is phenotypically expressed. Functional tests, combined with evaluation of the patient’s symptoms and responses to intervention, are necessary to assess the influence of known SNPs on the phenotype. DDI’s Plasma Methylation Profile is one such test; it provides a direct assessment of several major metabolites that indicate genetic and epigenetic affects. The Plasma Methylation Profile is a functional follow-up test when SNPs affecting methionine metabolism are identified.
DDI’s DNA Methylation Pathway Profile allows the opportunity to screen for a variety of SNPs that may impact the function of important biochemical processes. Identifying SNPs that influence health and potential health threats offer us the opportunity to begin to evaluate and understand how important lifestyle, nutrition (to include clean water and whole foods) in concert with restorative sleep, family and friends are when it comes to maximize health and wellness.
Turn Around Time
14 to 21 days
(May take longer based on weather, holiday or lab delays)